Nature Neuroscience

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Neural circuits for evidence accumulation and decision making in larval zebrafish

Nature Neuroscience, Published online: 02 December 2019; doi:10.1038/s41593-019-0534-9Bahl and Engert show that larval zebrafish can temporally integrate sensory information. The authors then use brain-wide functional imaging to search for, characterize and model brain areas that are well-suited to implement the underlying processes.

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http://feeds.nature.com/~r/neuro/rss/current/~3/uyL5HfoP1VU/s41593-019-0534-9

Silent synapses dictate cocaine memory destabilization and reconsolidation

Nature Neuroscience, Published online: 02 December 2019; doi:10.1038/s41593-019-0537-6Cocaine-generated silent synapses dictate the encoding, consolidation, retrieval-induced destabilization and reconsolidation of cocaine memories, and these syapses can be targeted to reduce drug seeking and relapse.

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http://feeds.nature.com/~r/neuro/rss/current/~3/HeJNeTNshxM/s41593-019-0537-6

Binocular viewing geometry shapes the neural representation of the dynamic three-dimensional environment

Nature Neuroscience, Published online: 02 December 2019; doi:10.1038/s41593-019-0544-7Bonnen et al. find that representations of 3D motion in primate cortical neurons have an unexpected structure that is shaped by the projection of the world onto the retinae. They demonstrate a link between this structure and human perceptual errors.

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http://feeds.nature.com/~r/neuro/rss/current/~3/mJlK8CUAJ98/s41593-019-0544-7

Evidence accumulation during a sensorimotor decision task revealed by whole-brain imaging

Nature Neuroscience, Published online: 02 December 2019; doi:10.1038/s41593-019-0535-8Dragomir et al. use a new decision-making assay in larval zebrafish to show that fish modulate their behavior depending on stimulus strength. A whole-brain imaging functional screen reveals neurons that integrate sensory evidence over the course of seconds.

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http://feeds.nature.com/~r/neuro/rss/current/~3/N7mRgzquF-Q/s41593-019-0535-8

α-Synuclein strains target distinct brain regions and cell types

Nature Neuroscience, Published online: 02 December 2019; doi:10.1038/s41593-019-0541-xLau et al. find that α-synuclein strains initiate distinct diseases when injected into mice, which provides a potential molecular explanation for the clinical and pathological differences between Parkinson’s disease and related neurodegenerative disorders.

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http://feeds.nature.com/~r/neuro/rss/current/~3/ucL5DxhxsO4/s41593-019-0541-x

The influence of environment and origin on brain resident macrophages and implications for therapy

Nature Neuroscience, Published online: 02 December 2019; doi:10.1038/s41593-019-0545-6Framed around the potential use of microglia as new cellular therapies for brain disease, Bennett and Bennett review new discoveries about the effects of developmental origin and environmental signals on brain macrophage identity and function.

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http://feeds.nature.com/~r/neuro/rss/current/~3/QF6AskIvo40/s41593-019-0545-6