American Journal of Obstetrics & Gynecology

Populational trends and outcomes of postoperative radiotherapy for high-risk early-stage cervical cancer with lymph node metastasis: concurrent chemo-radiotherapy versus radiotherapy alone

Pelvic lymph node metastasis carries the highest impact on decreased survival among surgical-pathological risk factors for early-stage cervical cancer. While concurrent administration of chemotherapy during postoperative radiotherapy is the current standard treatment for surgically-treated high-risk early-stage cervical cancer, its effectiveness specific to node-positive disease has not been completely studied.

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Short-term Quality of Life after Myomectomy for Uterine Fibroids from the Compare-UF Fibroid Registry

Uterine fibroids may decrease quality of life in a significant proportion of affected women. Myomectomy offers a uterine-sparing treatment option for patients with uterine fibroids that can be performed abdominally, laparoscopically (with or without robotic assistance), and by hysteroscopy. Quality of life using validated measures for different myomectomy routes, especially hysteroscopic myomectomy, is limited.

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https://www.ajog.org/article/S0002-9378(19)31235-9/fulltext?rss=yes

Intraoperative Tranexamic Acid to Decrease Blood Loss During Myomectomy: A Randomized Double-Blind Placebo Controlled Trial

Myomectomy is associated with a significant risk of hemorrhage. Tranexamic acid is a synthetic lysine derivative with antifibrinolytic activity used in other surgical disciplines to reduce blood loss during surgery. However, its utility in gynecologic surgery is not well understood.

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https://www.ajog.org/article/S0002-9378(20)30199-X/fulltext?rss=yes

Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy

The current coronavirus disease 2019 (COVID-19) pneumonia pandemic, caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) virus, is spreading globally at an accelerated rate, with a basic reproduction number (R0) of 2 – 2.5, indicating that 2 – 3 persons will be infected from an index patient. A serious public health emergency, it is particularly deadly in vulnerable populations and communities in which healthcare providers are insufficiently prepared to manage the infection. As of March 16, 2020, there are more than 180,000 confirmed cases of COVID-19 worldwide, with over 7,000 related deaths.

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https://www.ajog.org/article/S0002-9378(20)30343-4/fulltext?rss=yes

Placenta Accreta Spectrum: Biomarker Discovery using Plasma Proteomics

Many cases of placenta accreta spectrum (PAS) are not diagnosed antenatally, despite identified risk factors and improved imaging methods. Identification of plasma protein biomarkers could further improve antenatal diagnosis of PAS.

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https://www.ajog.org/article/S0002-9378(20)30341-0/fulltext?rss=yes

Addressing heterogenous outcomes in uterine fibroids research: a call to action

Uterine fibroids are the most common benign pelvic tumors in women, with complications including heavy menstrual bleeding, pelvic pain, reproductive complications, and bulk-related symptoms. While the majority of uterine fibroids are asymptomatic, those suffering from symptoms can experience substantial burdens on quality of life and daily functioning. Comparative effectiveness reviews into available medical, surgical, and radiological treatments have found that a lack of high-quality data to inform treatment decisions is due, in part, to the use of heterogeneous outcomes and instruments in clinical studies.

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https://www.ajog.org/article/S0002-9378(20)30340-9/fulltext?rss=yes

A Randomized Controlled Non-Inferiority Trial of Reduced Versus Routine Opioid Prescription after Prolapse Repair

Given the accelerating opioid crisis in the United States and evidence that patients use less opioid than prescribed, surgeons may choose to decrease prescribed quantities. The effect this may have on patient satisfaction with pain control after hospital discharge is unknown.

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https://www.ajog.org/article/S0002-9378(20)30339-2/fulltext?rss=yes

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